סירתה תטולב תוליעפל םירושקש םיטקפסא רפסמ ונחב םירקוחה
.םהייחל הנושארה הנשה ךלהמב לופיטב םלצא ויהש תוקונית לצא
יחמצ ל"מתב ונוזינ םהמ הנומשככ ,תוקונית 78 ונחבנ לכה ךס
.היוס סיסב לע אלש ונוזינ ראשה לכ וליאו ,היוס ססובמ
ךורא יתפורת לופיטו ,רתוי בר ןמז שורד היהש ואצמ םירקוחה
.היוסב ונזוהש תוקוניתב תויבויח תואצות לבקל תנמ לע ,רתוי
-ו ישפוח ןיסקורית לש הדידמו דומצ בקעמ שורד הלא תוקוניתב
םינונימל קקדזהל םילולע םהו ,(סירתה תטולב ןומרוה) TSH
עיגהל תנמ לע ןיסקוריתוול לש רתוי םיהובג םייתפורת
.סירתה תטולב לש תילמרונ תוליעפל
2004 תליחתב םסרופש - הז רקחמ תואצות
סירתה תטולב תוליעפל םיקזנ לע תויודע םע בטיה תובשיתמ
:הברה תושדחמ ןניא םג ךא ,היוס תכירצ ידי לע םימרגנש
תוקונית תנזהש רבכ וארה (הטמל ,ךשמהב טטוצמ) וירבחו טרופ
סיטידיורית לש םירקמ רתוי יצחו םיינש יפל המרג היוס בלחב
וא םירחא םיפילחתב ונזוהש תוקונית לצא רשאמ ינומיאוטוא
.םא בלחב
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Archives of Disease in Childhood 2004;89:37-40
Soy formula complicates management of congenital hypothyroidism
S C Conrad, H Chiu and B L Silverman
Department of Pediatrics, Northwestern University Medical School, Chicago, IL, USA
Correspondence to: Dr S C Conrad
Childrens Hospital Oakland, Division of Pediatric Endocrinology, 747 Fifty Second Street, Oakland, CA 94609, USA
sconrad@mail.cho.org
Aims: To test the hypothesis that feeding soy formula to infants with congenital hypothyroidism (CH) leads to prolonged increase of thyroid stimulating hormone (TSH). Methods: The study was a review of 78 patients seen during their first year of life between 1990 and 1998. Data regarding clinical diagnosis, date of treatment initiation, TSH, levothyroxine dose, weight, length, and diet information from each visit were collected from the charts.
Results: There were eight patients in the soy diet group and 70 in the non-soy diet group. There was no significant difference between the two groups in the starting dose of levothyroxine or the change in this dose over one year. There was a significant difference between the two groups in the following areas: time to TSH normalisation, first TSH on treatment, percentage with increased TSH at 4 months of age, percentage with increased TSH throughout the first year of life, and in the overall trend of TSH at each visit.
Conclusions: Infants fed soy formula had prolonged increase of TSH when compared to infants fed non-soy formula. These infants need close monitoring of free thyroxine and TSH measurements, and they may need increased levothyroxine doses to achieve normal thyroid function tests.
Keywords: hypothyroidism; thyroid function tests; soy formula; thyrotropin
Abbreviations: CH, congenital hypothyroidism; T4, thyroxine; TSH, thyroid stimulating hormone
Breast and soy-formula feedings in early infancy and the prevalence of autoimmune thyroid disease in children.
J Am Coll Nutr. 1990 Apr;9(2):164-7.
Fort P, Moses N, Fasano M, Goldberg T, Lifshitz F.
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
It has been suggested that feeding practices in infancy may affect the development of various autoimmune diseases later in life. Since thyroid alterations are among the most frequently encountered autoimmune conditions in children, we studied whether breast and soy-containing formula feedings in early life were associated with the subsequen. A detailed history of feeding practices was obtained in 59 children with autoimmune thyroid disease, their 76 healthy siblings, and 54 healthy nonrelated control children. There was no difference in the frequency and duration of breast feeding in early life among the three groups of children. However, the frequency of feedings with soy-based milk formulas in early life was significantly higher in children with autoimmune thyroid disease (prevalence 31%) as compared with their siblings (prevalence 12%; chi 2 = 7.22 with continuity factor; p less than 0.01), and healthy nonrelated control children (prevalence 13%, chi 2 = 5.03 with continuity factor; p less than 0.02). Therefore, this retrospective analysis documents the association of soy formula feedings in infancy and autoimmune thyroid disease.
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