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ןאכ
אוצמל ןתינ ומדוק תאשו ,תודלוח לע השענש ,הז רקחמ לע היוסב יוצמש ןיאטסינג ןגורטסאוטיפה לש ינגורטסא יטנא טקפא הארמ .םישנ לש תינימה תוגהנתהה לע םיעיפשמש םירטמרפ םינשב םירקחמה ןיבמ - םיבושחהמ ןכלו - םינושארהמ אוה הז רקחמ םירקחמה תיברמ .חמה תוליעפ לע ןיאטסינגה תעפשה תא הארמש - תונורחאה רקחמה .רבעמה ליג תועפותו ןטרס ,סירתה תטולב ומכ םיאשונב וקסע םויה דע .חמב םישחרתמש םיכילהת לע היוסמ יחמצ ףסות לש הרישי העפשה הארמ ונינפלש !תיבויח אלו ,הרישי העפשה |
Genistein Affects ER-sigma, But Not ER-alpha - Dependent Gene Expression in the HypothalamusHeather B. Patisaul, Melissa Melby, Patricia L. Whitten and Larry J. YoungCenter for Behavioral Neuroscience (H.B.P., P.L.W., L.J.Y.), Department of Anthropology (M.M., P.L.W.), and Department of Psychiatry and Behavioral Sciences (L.J.Y.), Emory University, Atlanta, Georgia 30329 |
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:םיאבה םירבדה תא םירקוחה םירמוא ,םוכיסל |
Genistein is one of the most common and abundant isoflavones, found in thousands of plant species, particularly the legumes. Soy and soy-based foods, including soy infant formula, contain the highest concentrations of genistein (8843 8843 ). Soy and isoflavone supplements, like the one used in these experiments, also contain significant quantities of genistein (8843 ). These and other phytoestrogen-rich foods are being heavily advertised as a healthy alternative to traditional ERT and are increasing in popularity as their beneficial effects on the heart and bones become more widely publicized.
We have now demonstrated that genistein, coumestrol, and a commercially prepared isoflavone supplement are antiestrogenic in the brain (8843 8843 ). The supplement produced these effects in adult, OVX, rats at levels lower than those needed to cause uterine proliferation in juvenile rats. All of the doses used for these studies were low enough to produce plasma levels in rats that equate to plasma levels of phytoestrogens commonly seen in humans (Table 2 ). Although effects on humans are difficult to predict from studies on rats, the results of these studies suggest that although phytoestrogens may confer a variety of benefits, including a reduced risk of heart disease and cancer due to their estrogenic activity in the periphery, their antiestrogenic actions in the brain may indicate that they do not confer the same mental health benefits as traditional ERT. (8843 8843 8843 8843 8843 ) |
.ןאכ אוצמל ןתינ אלמה רמאמה תא
לכואב םינובלפוזיאה תומכ תא תזכרמש הלבט : אבה דומעל |